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Article

IDH mutation is associated with higher risk of malignant transformation in low-grade glioma.

Journal of neuro-oncology - 1 Apr 2016

Leu Severina, von Felten Stefanie, Frank Stephan, Boulay Jean-Louis, Mariani Luigi

Abstract excerpt

Acquisition of IDH1 or IDH2 mutation (IDHmut) is among the earliest genetic events that take place in the development of most low-grade glioma (LGG). IDHmut has been associated with longer overall patient survival. However, its impact on malignant transformation (MT) remains to be defined. A collection of 210 archived adult LGG previously stratified by IDHmut, MGMT methylation (MGMTmet), 1p/19q combined loss of...

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Share to Brain Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26780338
DOI: 10.1007/s11060-015-2048-y

Genes

IDH1
IDH2
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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