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Article

IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival.

Neuro-oncology - 1 Apr 2013

Leu Severina, von Felten Stefanie, Frank Stephan, Vassella Erik, Vajtai Istvan, Taylor Elisabeth, Schulz Marianne, Hutter Gregor, Hench Jürgen, Schucht Philippe, Boulay Jean-Louis, Mariani Luigi

Abstract excerpt

BACKGROUND: Low-grade gliomas (LGGs) are rare brain neoplasms, with survival spanning up to a few decades. Thus, accurate evaluations on how biomarkers impact survival among patients with LGG require long-term studies on samples prospectively collected over a long period. METHODS: The 210 adult LGGs collected in our databank were screened for IDH1 and IDH2 mutations (IDHmut), MGMT gene promoter methylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23408861
DOI: 10.1093/neuonc/nos317
PMCID: PMC3607260

Genes

MGMT
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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