Article

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

2020-12-11

Abstract excerpt

Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency in several tumour types. Even though these mutations are confined to distinct hotspots, we show that gliomas are the only tumour type with an exceptionally high percentage of IDH1 R132H mutations. This high prevalence is important as IDH1 R132H is presumed to be relatively poor at producing D-2-hydroxyglutarate (D-2HG...

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Literature Corpus work: c646df65-a70b-5167-90ef-03ecd459279a
DOI: 10.1101/2020.12.10.419333

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