Article
Impact of IDH mutation and MGMT methylation as Independent prognostic markers in uniformly treated high grade glioma Patients: A Real-World evidence in the Indian Population.
Brain research - 15 Apr 2026
Kumar Anuj, Gurav Mamta, Sarkar Joyita, Bapat Prachi, Madhu Kalyani, Shetty Omshree, Chatterjee Abhishek, Sahay Ayushi, Dasgupta Archya, Moiyadi Aliasgar, Shetty Prakash, Gupta Tejpal, Goda Jayant S, Epari Sridhar
Abstract excerpt
IDH-mutant (IDHmt) high-grade gliomas (HGG) differ significantly from IDH-wildtype (IDHwt) HGG, or glioblastoma (GBM). MGMT promoter methylation (MGMTp) is an established prognostic marker in GBM, but its role in IDHmt HGG remains unclear. We evaluated the prognostic impact of IDH mutation and MGMTp in 395 uniformly treated HGG patients in India. All patients underwent maximal safe resection followed by adjuvant...
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