Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2016

Revollo Javier, Petibone Dayton M, McKinzie Page, Knox Bridgett, Morris Suzanne M, Ning Baitang, Dobrovolsky Vasily N

Abstract excerpt

Closely related TK6, WTK1, and NH32 human B-lymphoblastoid cell lines differ in their p53 functional status. These lines are used frequently in genotoxicity studies and in studies aimed at understanding the role of p53 in DNA repair. Despite their routine use, little is known about the genetic status of these cells. To provide insight into their genetic composition, we sequenced and analyzed the entire genome of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferric Compounds
Share to Ferritins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frameshift Mutation

Share to Iron Metabolism Disorders

Share to Methyltransferases

Share to NAD(P)H Dehydrogenase (Quinone)

Share to Oxidoreductases

Share to Thioguanine

Source

Identifiers

PMID: 26774668
DOI: 10.1016/j.mrgentox.2015.11.006

Genes

NQO1
TPMT
FTH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines.PMID 26774668Read ↗

TK6 genome profile compared with WIL2-NS: Reference data to improve the reproducibility of genotoxicity studies.Semantic proximity Read ↗

Error-corrected Duplex Sequencing enables direct detection and quantification of mutations in human TK6 cells with remarkable inter-laboratory consistencySemantic proximity Read ↗

Background Mutation Frequencies in TK6 and L5178Y Cells: Implications for Error-Corrected Sequencing.Semantic proximity Read ↗

Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency.Semantic proximity Read ↗

PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosisSemantic proximity Read ↗

Novel next-generation sequencing-based methodologies to characterize the mutational consequences of (prenatal) chemotherapy exposure in noncancerous tissue.Semantic proximity Read ↗

Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics.Semantic proximity Read ↗

Whole genome sequencing of mouse lymphoma L5178Y-3.7.2C (TK+/-) reveals millions of mutations and genetic markers.Semantic proximity Read ↗

Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.Semantic proximity Read ↗

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.Semantic proximity Read ↗

Mutational spectrum of X-ray induced TK- human cell mutants.Semantic proximity Read ↗

Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.