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Article

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.

Pharmacogenomics - 1 Mar 2014

Matimba Alice, Li Fang, Livshits Alina, Cartwright Cher S, Scully Stephen, Fridley Brooke L, Jenkins Gregory, Batzler Anthony, Wang Liewei, Weinshilboum Richard, Lennard Lynne

Abstract excerpt

AIM: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. MATERIALS & METHODS: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine cytotoxicity using lymphoblastoid cell lines. We then genotyped the top SNPs associated with lymphoblastoid cell line cytotoxicity, together with tagSNPs for genes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24624911
DOI: 10.2217/pgs.13.226
PMCID: PMC4027966

Genes

ABCC4
ABCC5
GNG2
IMPDH1
ITPA
KCNMA1
NME1
XDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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