Article
Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.
Carcinogenesis - 1 Jan 2009
Lan Qing, Zhang Luoping, Shen Min, Jo William J, Vermeulen Roel, Li Guilan, Vulpe Christopher, Lim Sophia, Ren Xuefeng, Rappaport Stephen M, Berndt Sonja I, Yeager Meredith, Yuenger Jeff, Hayes Richard B, Linet Martha, Yin Songnian, Chanock Stephen, Smith Martyn T, Rothman Nathaniel
Abstract excerpt
Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced hematotoxicity, we analyzed 1395 SNPs in 411 genes using an Illumina GoldenGate assay in 250 benzene-exposed workers and 140 unexposed controls. Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and...
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