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Whole genome sequencing of mouse lymphoma L5178Y-3.7.2C (TK+/-) reveals millions of mutations and genetic markers.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Feb 2017

McKinzie Page B, Revollo Javier R

Abstract excerpt

The mouse lymphoma L5178Y-3.7.2C (TK+/-) cell line is extensively used in genetic toxicology to conduct the mouse lymphoma assay (MLA). The MLA is used to establish the mutagenic and clastogenic effects of chemicals and pharmaceuticals, and is one of the few genetic tests widely accepted by regulatory agencies throughout the world. Despite the extensive use and regulatory impact of L5178Y-3.7.2C (TK+/-) cells,...

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PMID: 28137362
DOI: 10.1016/j.mrgentox.2016.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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