Article
A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.
FEBS letters - 1 Jan 2016
Zhou Xin, Zeng Jia, Ouyang Chenxi, Luo Qianyun, Yu Miao, Yang Zhenrong, Wang Hui, Shen Kang, Shi Anbing
Abstract excerpt
Potassium channels such as Kv2.1 are targeted to specific subcellular compartments to fulfill various functions. However, the mechanisms for their localization are poorly understood. Here, we show that KVS-4/Kv2.1 somatodendritic localization in Caenorhabditis elegansDA9 neuron requires UNC-101(AP-1 μ subunit). We define a bipartite sorting signal within KVS-4 consisting of a C-terminal EQMIL and N-terminal WNIIE...
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