Article
Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway.
The Journal of cell biology - 7 Nov 2005
Hasdemir Burcu, Fitzgerald Daniel J, Prior Ian A, Tepikin Alexei V, Burgoyne Robert D
Abstract excerpt
The traffic of Kv4 K+ channels is regulated by the potassium channel interacting proteins (KChIPs). Kv4.2 expressed alone was not retained within the ER, but reached the Golgi complex. Coexpression of KChIP1 resulted in traffic of the channel to the plasma membrane, and traffic was abolished when mutations were introduced into the EF-hands with channel captured on vesicular structures that colocalized with...
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