Article
HID-1, a new component of the peptidergic signaling pathway.
Genetics - 1 Feb 2011
Mesa Rosana, Luo Shuo, Hoover Christopher M, Miller Kenneth, Minniti Alicia, Inestrosa Nibaldo, Nonet Michael L
Abstract excerpt
hid-1 was originally identified as a Caenorhabditis elegans gene encoding a novel conserved protein that regulates the decision to enter into the enduring dauer larval stage. We isolated a novel allele of hid-1 in a forward genetic screen for mutants mislocalizing RBF-1 rabphilin, a RAB-27 effector. Here we demonstrate that HID-1 functions in the nervous system to regulate neuromuscular signaling and in the...
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