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Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans

3 Apr 2025

Abstract excerpt

Therapeutic use of tiny extracellular vesicles (EVs) requires understanding cargo loading mechanisms. Here, we use a modular proximity labeling approach to identify the cargo of ciliary EVs associated with the transient receptor potential channel polycystin-2 PKD-2 of C. elegans. Polycystins are conserved ciliary proteins and cargo of EVs; dysfunction causes polycystic kidney disease in humans and mating deficits...

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PMID: 40180912
DOI: 10.1038/s41467-025-57512-3

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