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Article

The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.

PLoS genetics - 1 May 2016

Topalidou Irini, Cattin-Ortolá Jérôme, Pappas Andrea L, Cooper Kirsten, Merrihew Gennifer E, MacCoss Michael J, Ailion Michael

Abstract excerpt

The dense-core vesicle is a secretory organelle that mediates the regulated release of peptide hormones, growth factors, and biogenic amines. Dense-core vesicles originate from the trans-Golgi of neurons and neuroendocrine cells, but it is unclear how this specialized organelle is formed and acquires its specific cargos. To identify proteins that act in dense-core vesicle biogenesis, we performed a forward...

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Identifiers

PMID: 27191843
DOI: 10.1371/journal.pgen.1006074
PMCID: PMC4871572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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