Article

Analysis of gene expression and mutation data points on contribution of transcription to the mutagenesis by APOBEC enzymes

2021-04-14

Abstract excerpt

Since the discovery of the role of the APOBEC enzymes in human cancers, the mechanisms of this type of mutagenesis remain little understood. Theoretically, targeting of single-stranded DNA by the APOBEC enzymes could occur during cellular processes leading to the unwinding of DNA double-stranded structure. Some evidence points to the importance of replication in the APOBEC mutagenesis, while the role of transcript...

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Literature Corpus work: 00be6036-d07f-5b5f-851a-7638efbab02a
DOI: 10.1101/2021.04.14.439818

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