Article
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.
Nature - 1 Feb 2022
Bergstrom Erik N, Luebeck Jens, Petljak Mia, Khandekar Azhar, Barnes Mark, Zhang Tongwu, Steele Christopher D, Pillay Nischalan, Landi Maria Teresa, Bafna Vineet, Mischel Paul S, Harris Reuben S, Alexandrov Ludmil B
Abstract excerpt
Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1-5, diffuse hypermutation termed omikli6, and longer strand-coordinated events termed kataegis3,7-9. Here we provide a comprehensive characterization of clustered substitutions and clustered small insertions and deletions...
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