Article
Skin Cancer Risk Is Modified by KIR/HLA Interactions That Influence the Activation of Natural Killer Immune Cells.
Cancer research - 15 Jan 2016
Vineretsky Karin A, Karagas Margaret R, Christensen Brock C, Kuriger-Laber Jacquelyn K, Perry Ann E, Storm Craig A, Nelson Heather H
Abstract excerpt
Natural killer (NK)-cell phenotype is partially mediated through binding of killer-cell immunoglobulin-like receptors (KIR) with HLA class I ligands. The KIR gene family is highly polymorphic and not well captured by standard genome-wide association study approaches. Here, we tested the hypothesis that variations in KIR gene content combined with HLA class I ligand status is associated with keratinocyte skin...
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