Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma.

doi:10.1038/s41467-020-14594-5

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Article

Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma.

Nature communications - 10 Feb 2020

Sarin Kavita Y, Lin Yuan, Daneshjou Roxana, Ziyatdinov Andrey, Thorleifsson Gudmar, Rubin Adam, Pardo Luba M, Wu Wenting, Khavari Paul A, Uitterlinden Andre, Nijsten Tamar, Toland Amanda E, Olafsson Jon H, Sigurgeirsson Bardur, Thorisdottir Kristin, Jorgensen Eric, Whittemore Alice S, Kraft Peter, Stacey Simon N, Stefansson Kari, Asgari Maryam M, Han Jiali

Abstract excerpt

Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with cutaneous SCC. Here, we report the largest cutaneous SCC meta-analysis to date, representing six international cohorts and totaling 19,149 SCC cases and 680,049 controls. We discover eight novel...

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Identifiers

PMID: 32041948
DOI: 10.1038/s41467-020-14594-5
PMCID: PMC7010741

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