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Article

Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma.

Cancer immunology, immunotherapy : CII - 1 Jul 2018

Wang Wei, Ollila Hanna M, Whittemore Alice S, Demehri Shadmehr, Ioannidis Nilah M, Jorgenson Eric, Mignot Emmanuel, Asgari Maryam M

Abstract excerpt

BACKGROUND: The immune system has been implicated in the pathophysiology of cutaneous squamous cell carcinoma (cSCC) as evidenced by the substantially increased risk of cSCC in immunosuppressed individuals. Associations between cSCC risk and single nucleotide polymorphisms (SNPs) in the HLA region have been identified by genome-wide association studies (GWAS). The translation of the associated HLA SNPs to...

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Share to Carcinoma, Squamous Cell
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 29754218
DOI: 10.1007/s00262-018-2168-2
PMCID: PMC7081741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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