Article
New basal cell carcinoma susceptibility loci.
Nature communications - 9 Apr 2015
Stacey Simon N, Helgason Hannes, Gudjonsson Sigurjon A, Thorleifsson Gudmar, Zink Florian, Sigurdsson Asgeir, Kehr Birte, Gudmundsson Julius, Sulem Patrick, Sigurgeirsson Bardur, Benediktsdottir Kristrun R, Thorisdottir Kristin, Ragnarsson Rafn, Fuentelsaz Victoria, Corredera Cristina, Gilaberte Yolanda, Grasa Matilde, Planelles Dolores, Sanmartin Onofre, Rudnai Peter, Gurzau Eugene, Koppova Kvetoslava, Nexø Bjørn A, Tjønneland Anne, Overvad Kim, Jonasson Jon G, Tryggvadottir Laufey, Johannsdottir Hrefna, Kristinsdottir Anna M, Stefansson Hreinn, Masson Gisli, Magnusson Olafur T, Halldorsson Bjarni V, Kong Augustine, Rafnar Thorunn, Thorsteinsdottir Unnur, Vogel Ulla, Kumar Rajiv, Nagore Eduardo, Mayordomo José I, Gudbjartsson Daniel F, Olafsson Jon H, Stefansson Kari
Abstract excerpt
In an ongoing screen for DNA sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conduct a genome-wide association study (GWAS) of 24,988,228 SNPs and small indels detected through whole-genome sequencing of 2,636 Icelanders and imputed into 4,572 BCC patients and 266,358 controls. Here we show the discovery of four new BCC susceptibility loci: 2p24 MYCN (rs57244888[C], OR=0.76, P=4.7 ×...
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