Article
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
Human molecular genetics - 15 Sept 2011
Nan Hongmei, Xu Mousheng, Kraft Peter, Qureshi Abrar A, Chen Constance, Guo Qun, Hu Frank B, Curhan Gary, Amos Christopher I, Wang Li-E, Lee Jeffrey E, Wei Qingyi, Hunter David J, Han Jiali
Abstract excerpt
We conducted a genome-wide association study on cutaneous basal cell carcinoma (BCC) among 2045 cases and 6013 controls of European ancestry, with follow-up replication in 1426 cases and 4845 controls. A non-synonymous SNP in the MC1R gene (rs1805007 encoding Arg151Cys substitution), a previously well-documented pigmentation gene, showed the strongest association with BCC risk in the discovery set (rs1805007[T]:...
Topics
- Adult
- Aged
- Alleles
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell