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Article

Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE.

BMC biology - 24 Aug 2022

Gao Galen F, Liu Dajiang, Zhan Xiaowei, Li Bo

Abstract excerpt

BACKGROUND: Natural killer (NK) cells represent a critical component of the innate immune system's response against cancer and viral infections, among other diseases. To distinguish healthy host cells from infected or tumor cells, killer immunoglobulin receptors (KIR) on NK cells bind and recognize Human Leukocyte Antigen (HLA) complexes on their target cells. However, NK cells exhibit great diversity in their...

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Identifiers

PMID: 36002830
DOI: 10.1186/s12915-022-01392-2
PMCID: PMC9400285

Genes

KIR3DL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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