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Article

Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility.

Genome medicine - 6 Feb 2021

Adolphe Christelle, Xue Angli, Fard Atefeh Taherian, Genovesi Laura A, Yang Jian, Wainwright Brandon J

Abstract excerpt

BACKGROUND: Basal cell carcinoma (BCC) of the skin is the most common form of human cancer, with more than 90% of tumours presenting with clear genetic activation of the Hedgehog pathway. However, polygenic risk factors affecting mechanisms such as DNA repair and cell cycle checkpoints or which modulate the tumour microenvironment or host immune system play significant roles in determining whether genetic...

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Identifiers

PMID: 33549134
DOI: 10.1186/s13073-021-00827-9
PMCID: PMC7866769

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