Article
KIR gene variability in cutaneous malignant melanoma: influence of KIR2D/HLA-C pairings on disease susceptibility and prognosis.
Immunogenetics - 1 May 2013
Campillo José A, Legaz Isabel, López-Álvarez M Rocío, Bolarín José Miguel, Las Heras Beatriz, Muro Manuel, Minguela Alfredo, Moya-Quiles María R, Blanco-García Rosa, Martínez-Banaclocha Helios, García-Alonso Ana M, Alvarez-López M Rocío, Martínez-Escribano Jorge A
Abstract excerpt
Natural killer and CD8(+) T cells are believed to be involved in the immune protection against melanoma. Their function may be regulated by a group of receptors defined as killer immunoglobulin-like receptors (KIRs) and their cognate HLA class I ligands. In this study, we analyzed the influence of KIR genes and KIR/HLA-I combinations on melanoma susceptibility and/or prognosis in a Spanish Caucasian population....
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