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Article

Role of LRRK2 in axonal transport and Parkinson's disease.

The Biochemical journal - 25 Jun 2025

Twellsieck Björn, Boecker C Alexander

Abstract excerpt

Axonal transport is crucial for neuronal health and function, facilitating the delivery of newly synthesized material from the soma via anterograde transport and the removal of aged proteins and damaged organelles for degradation via retrograde transport. Emerging evidence links Parkinson's disease (PD)-causing mutations in the leucine-rich repeat kinase 2 (LRRK2) gene to dysfunctional axonal transport....

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Identifiers

PMID: 40570189
DOI: 10.1042/BCJ20253133
PMCID: PMC12312394

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