Article
LRRK2 and Autophagy.
Advances in neurobiology - 1 Jan 2017
Manzoni Claudia, Lewis Patrick A
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2) has been implicated in a wide range of cellular processes, including the catabolic pathways collectively described as autophagy. In this chapter, the evidence linking LRRK2 to autophagy will be examined, along with how regulation of autophagy and lysosomal pathways may provide a nexus between the physiological function of this protein and the different diseases with which it...
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