Article
LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.
The Biochemical journal - 28 May 2025
Buck Silas A, Sanders Laurie H
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms including tremor, rigidity, and bradykinesia as well as degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). A minority of PD cases are familial and are caused by a single geneti...
Topics
- Humans
- Parkinson Disease
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mitochondria
- Animals
- Mutation
- Oxidative Stress
- Dopaminergic Neurons