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Article

LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.

The Biochemical journal - 28 May 2025

Buck Silas A, Sanders Laurie H

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms including tremor, rigidity, and bradykinesia as well as degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). A minority of PD cases are familial and are caused by a single genetic mutation. One of the most common PD-causing genes is leucine-rich repeat kinase 2 (LRRK2), which causes an autosomal...

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Identifiers

PMID: 40440058
DOI: 10.1042/BCJ20253062
PMCID: PMC12181902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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