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Article

LRRK2 and mitochondria: Recent advances and current views.

Brain research - 1 Jan 2019

Singh Alpana, Zhi Lianteng, Zhang Hui

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene account for most common causes of familial and sporadic Parkinson's disease (PD) and are one of the strongest genetic risk factors in sporadic PD. Pathways implicated in LRRK2-dependent neurodegeneration include cytoskeletal dynamics, ves...

Topics

Autophagy
Calcium
Cytoskeleton
Dopaminergic Neurons
Homeostasis
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mitochondria
Mutation
Neurodegenerative Diseases
Neurons
Oxidative Stress
Parkinson Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 29894679
DOI: 10.1016/j.brainres.2018.06.010
PMCID: PMC6281802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-29894679-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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