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Article

LRRK2 and mitochondria: Recent advances and current views.

Brain research - 1 Jan 2019

Singh Alpana, Zhi Lianteng, Zhang Hui

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene account for most common causes of familial and sporadic Parkinson's disease (PD) and are one of the strongest genetic risk factors in sporadic PD. Pathways implicated in LRRK2-dependent neurodegeneration include cytoskeletal dynamics, vesicular trafficking, autophagy, mitochondria, and calcium homeostasis. However, the exact molecular mechanisms still...

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Identifiers

PMID: 29894679
DOI: 10.1016/j.brainres.2018.06.010
PMCID: PMC6281802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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