Article
Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer.
PLoS genetics - 1 Jan 2016
Halabi Najeeb M, Martinez Alejandra, Al-Farsi Halema, Mery Eliane, Puydenus Laurence, Pujol Pascal, Khalak Hanif G, McLurcan Cameron, Ferron Gwenael, Querleu Denis, Al-Azwani Iman, Al-Dous Eman, Mohamoud Yasmin A, Malek Joel A, Rafii Arash
Abstract excerpt
Identifying genes where a variant allele is preferentially expressed in tumors could lead to a better understanding of cancer biology and optimization of targeted therapy. However, tumor sample heterogeneity complicates standard approaches for detecting preferential allele expression. We therefore developed a novel approach combining genome and transcriptome sequencing data from the same sample that corrects for...
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