Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic selection of amplicons in glioblastoma revealed by combining somatic and germline analysis.

PLoS genetics - 2 Sept 2010

LaFramboise Thomas, Dewal Ninad, Wilkins Katherine, Pe'er Itsik, Freedman Matthew L

Abstract excerpt

Cancer is a disease driven by a combination of inherited risk alleles coupled with the acquisition of somatic mutations, including amplification and deletion of genomic DNA. Potential relationships between the inherited and somatic aspects of the disease have only rarely been examined on a genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ErbB Receptors
Share to Gene Amplification
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Glioblastoma

Share to GTPase-Activating Proteins

Share to Odds Ratio

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20824129
DOI: 10.1371/journal.pgen.1001086
PMCID: PMC2932683

Genes

DOCK4
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20824129-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic selection of amplicons in glioblastoma revealed by combining somatic and germline analysis.PMID 20824129Read ↗

RNA allelic frequencies of somatic mutations encode substantial functional information in cancersSemantic proximity Read ↗

EGFR gene variants are associated with specific somatic aberrations in glioma.Semantic proximity Read ↗

Receptor Tyrosine Kinase Genes Amplified in Glioblastoma Exhibit a Mutual Exclusivity in Variable Proportions Reflective of Individual Tumor HeterogeneitySemantic proximity Read ↗

Beyond sequence variation: assessment of copy number variation in adult glioblastoma through targeted tumor somatic profilingSemantic proximity Read ↗

Prospective, high-throughput molecular profiling of human gliomas.Semantic proximity Read ↗

Power to detect selective allelic amplification in genome-wide scans of tumor data.Semantic proximity Read ↗

High-resolution global genomic survey of 178 gliomas reveals novel regions of copy number alteration and allelic imbalances.Semantic proximity Read ↗

Shared Cancer Dataset Analysis Identifies and Predicts the Quantitative Effects of Pan-Cancer Somatic Driver Variants.Semantic proximity Read ↗

The Somatic Genomic Landscape of GlioblastomaSemantic proximity Read ↗

Germline cancer gene expression quantitative trait loci influence local and global tumor mutationsSemantic proximity Read ↗

Germline Cancer Gene Expression Quantitative Trait Loci Are Associated with Local and Global Tumor Mutations.Semantic proximity Read ↗

Elucidating the molecular pathogenesis of glioma: integrated germline and somatic profiling of a familial glioma case series.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.