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Article

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

21 Nov 2018

Abstract excerpt

Cancer immunotherapy has emerged as an effective therapy in a variety of cancers. However, a key challenge in the field is that only a subset of patients who receive immunotherapy exhibit durable response. It has been hypothesized that host genetics influences the inherent immune profiles of patients and may underlie their differential response to immunotherapy. Herein, we systematically determined the...

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PMID: 30463956
DOI: 10.1073/pnas.1804506115

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