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Article

Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity.

Circulation - 2 Oct 2012

He Lan, Kim Teayoun, Long Qinqiang, Liu Jian, Wang Peiyong, Zhou Yiqun, Ding Yishu, Prasain Jeevan, Wood Philip A, Yang Qinglin

Abstract excerpt

BACKGROUND: Carnitine palmitoyltransferase-1 (CPT1) is a rate-limiting step of mitochondrial β-oxidation by controlling the mitochondrial uptake of long-chain acyl-CoAs. The muscle isoform, CPT1b, is the predominant isoform expressed in the heart. It has been suggested that inhibiting CPT1 activity by specific CPT1 inhibitors exerts protective effects against cardiac hypertrophy and heart failure. However,...

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Identifiers

PMID: 22932257
DOI: 10.1161/CIRCULATIONAHA.111.075978
PMCID: PMC3484985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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