Article

Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

2021-06-22

Abstract excerpt

<h4>Summary</h4> Diabetic heart disease is highly prevalent and characterized by diastolic dysfunction. The mechanisms of diabetic heart disease are poorly understood and no targeted therapies are available. Here we show that the diabetic myocardium (type 1 and type 2) is characterized by marked glycogen elevation and ectopic cellular localization - a paradoxical metabolic pathology given suppressed cardiomyocyte...

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Literature Corpus work: 1464ffdc-3268-5013-8c75-824c24287e6d
DOI: 10.1101/2021.06.21.449174

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