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Article

A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2023

Velagic Anida, Li Mandy, Deo Minh, Li Jasmin Chendi, Kiriazis Helen, Donner Daniel G, Anderson Dovile, De Blasio Miles J, Woodman Owen L, Kemp-Harper Barbara K, Qin Cheng Xue, Ritchie Rebecca H

Abstract excerpt

Left ventricular (LV) dysfunction is an early, clinically detectable sign of cardiomyopathy in type 2 diabetes mellitus (T2DM) that precedes the development of symptomatic heart failure. Preclinical models of diabetic cardiomyopathy are essential to develop therapies that may prevent or delay the progression of heart failure. This study examined the molecular, structural, and functional cardiac phenotype of two...

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Share to Diabetes Mellitus, Experimental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

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Share to Rats, Sprague-Dawley

Share to Streptozocin

Share to Ventricular Dysfunction, Left

Source

Identifiers

PMID: 36607798
DOI: 10.1152/ajpheart.00390.2022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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