Article
Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.
American journal of physiology. Heart and circulatory physiology - 1 Dec 2017
Wende Adam R, Kim Jaetaek, Holland William L, Wayment Benjamin E, O'Neill Brian T, Tuinei Joseph, Brahma Manoja K, Pepin Mark E, McCrory Mark A, Luptak Ivan, Halade Ganesh V, Litwin Sheldon E, Abel E Dale
Abstract excerpt
Pathological cardiac hypertrophy may be associated with reduced expression of glucose transporter 4 (GLUT4) in contrast to exercise-induced cardiac hypertrophy, where GLUT4 levels are increased. However, mice with cardiac-specific deletion of GLUT4 (G4H-/-) have normal cardiac function in the unstressed state. This study tested the hypothesis that cardiac GLUT4 is required for myocardial adaptations to...
Topics
- 3-Hydroxyacyl CoA Dehydrogenases
- Adaptation, Physiological
- Animals
- Aorta
- Cardiomegaly
- Cardiomegaly, Exercise-Induced
- Carnitine O-Palmitoyltransferase
- Constriction
- Disease Models, Animal