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Article

Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy.

Cardiovascular diabetology - 16 Apr 2025

Asakura Junko, Nagao Manabu, Shinohara Masakazu, Hosooka Tetsuya, Kuwahara Naoya, Nishimori Makoto, Tanaka Hidekazu, Satomi-Kobayashi Seimi, Matsui Sho, Sasaki Tsutomu, Kitamura Tadahiro, Otake Hiromasa, Ishida Tatsuro, Ogawa Wataru, Hirata Ken-Ichi, Toh Ryuji

Abstract excerpt

BACKGROUND: Systemic insulin resistance plays an important role in the pathogenesis of type 2 diabetes and its complications. Although impaired branched-chain amino acid (BCAA) metabolism has been reported to be involved in the development of diabetes, the relationship between cardiac BCAA metabolism and the pathogenesis of diabetic cardiomyopathy (DbCM) remains unclear. OBJECTIVES: The aim of this study was to...

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Share to 3-Phosphoinositide-Dependent Protein Kinases
Share to Amino Acids, Branched-Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40240904
DOI: 10.1186/s12933-025-02725-5
PMCID: PMC12004671

Genes

PDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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