Article
RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification.
PLoS genetics - 1 Dec 2015
Arimbasseri Aneeshkumar G, Blewett Nathan H, Iben James R, Lamichhane Tek N, Cherkasova Vera, Hafner Markus, Maraia Richard J
Abstract excerpt
Control of the differential abundance or activity of tRNAs can be important determinants of gene regulation. RNA polymerase (RNAP) III synthesizes all tRNAs in eukaryotes and it derepression is associated with cancer. Maf1 is a conserved general repressor of RNAP III under the control of the target of rapamycin (TOR) that acts to integrate transcriptional output and protein synthetic demand toward metabolic...
Topics
- Amino Acid Sequence
- Gene Expression Regulation, Fungal
- HEK293 Cells
- Humans
- Molecular Sequence Data
- Mutation
- RNA Polymerase III
- RNA, Transfer
- RNA, Transfer, Ser
- Repressor Proteins
- Saccharomyces cerevisiae Proteins
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins