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Article

Genome-wide analysis of N<sup>1</sup>-methyl-adenosine modification in human tRNAs

19 May 2010

Abstract excerpt

The N(1)-methyl-Adenosine (m(1)A58) modification at the conserved nucleotide 58 in the TPsiC loop is present in most eukaryotic tRNAs. In yeast, m(1)A58 modification is essential for viability because it is required for the stability of the initiator-tRNA(Met). However, m(1)A58 modification is not required for the stability of several other tRNAs in yeast. This differential m(1)A58 response for different tRNA...

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PMID: 20484468
DOI: 10.1261/rna.2057810

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