Article

Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species

2022-04-25

Abstract excerpt

All tRNAs have numerous modifications, lack of which often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae , lack of tRNA body modifications can lead to impaired tRNA stability and decay of a subset of the hypomodified tRNAs. Mutants lacking 7-methylguanosine at G 46 (m 7 G 46 ), N 2 ,N 2 -dimethylguanosine (m 2,2 G 26...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1537fe43-8455-5cbc-ad42-24bbb397f2c6
DOI: 10.1101/2022.04.25.489336

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast speciesDOI 10.1101/2022.04.25.489336Read

Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequencesSemantic proximity Read

Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.Semantic proximity Read

The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA.Semantic proximity Read

A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay.Semantic proximity Read

Degradation of hypomodified tRNA(iMet) in vivo involves RNA-dependent ATPase activity of the DExH helicase Mtr4p.Semantic proximity Read

Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway.Semantic proximity Read

The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets.Semantic proximity Read

Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation.Semantic proximity Read

Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)U.Semantic proximity Read

The mammalian rapid tRNA decay pathway is critical for N⁷-methylguanosine-hypomodified tRNA degradation under physiological conditionsSemantic proximity Read

Methylated nucleosides in tRNA and tRNA methyltransferasesSemantic proximity Read

The Biology of tRNA t6A Modification and Hypermodifications—Biogenesis and Disease RelevanceSemantic proximity Read