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Article

A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay.

PLoS genetics - 1 Jan 2024

De Zoysa Thareendra, Hauke Alayna C, Iyer Nivedita R, Marcus Erin, Ostrowski Sarah M, Stegemann Franziska, Ermolenko Dmitri N, Fay Justin C, Phizicky Eric M

Abstract excerpt

tRNA modifications are crucial in all organisms to ensure tRNA folding and stability, and accurate translation. In both the yeast Saccharomyces cerevisiae and the evolutionarily distant yeast Schizosaccharomyces pombe, mutants lacking certain tRNA body modifications (outside the anticodon loop) are temperature sensitive due to rapid tRNA decay (RTD) of a subset of hypomodified tRNAs. Here we show that for each of...

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PMID: 38295128
DOI: 10.1371/journal.pgen.1011146
PMCID: PMC10861057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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