Article

Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences

2020-05-29

Abstract excerpt

All tRNAs are extensively modified, and modification deficiency often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae , lack of any of several tRNA body modifications results in rapid tRNA decay (RTD) of certain mature tRNAs by the 5’-3’ exonucleases Rat1 and Xrn1. As tRNA quality control decay mechanisms are not extensively...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55dbf801-1513-584e-b69b-09bcd46f8ac4
DOI: 10.1101/2020.05.29.123083

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequencesDOI 10.1101/2020.05.29.123083Read

Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast speciesSemantic proximity Read

A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay.Semantic proximity Read

The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA.Semantic proximity Read

Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway.Semantic proximity Read

The mammalian rapid tRNA decay pathway is critical for N⁷-methylguanosine-hypomodified tRNA degradation under physiological conditionsSemantic proximity Read

Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.Semantic proximity Read

Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase PSemantic proximity Read

Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation.Semantic proximity Read

Methylated nucleosides in tRNA and tRNA methyltransferasesSemantic proximity Read

Widespread temperature sensitivity and tRNA decay due to mutations in a yeast tRNA.Semantic proximity Read

Mistranslating tRNA variants impact the proteome and phosphoproteome of <i>Saccharomyces cerevisiae</i>Semantic proximity Read

tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.Semantic proximity Read