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Article

Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.

Genes & development - 1 Jun 2004

Kadaba Sujatha, Krueger Anna, Trice Tamyra, Krecic Annette M, Hinnebusch Alan G, Anderson James

Abstract excerpt

The tRNA m(1)A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m(1)A methyltransferase (Mtase) and a temperature-sensitive growth phenotype that is attributable to the absence of m(1)A58 and consequential tRNA(i)(Met) instability. We used a genetic approach to identify the genes responsible for...

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PMID: 15145828
DOI: 10.1101/gad.1183804
PMCID: PMC420349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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