Article
Altered brain activation in a reversal learning task unmasks adaptive changes in cognitive control in writer's cramp.
NeuroImage. Clinical - 1 Jan 2016
Zeuner Kirsten E, Knutzen Arne, Granert Oliver, Sablowsky Simone, Götz Julia, Wolff Stephan, Jansen Olav, Dressler Dirk, Schneider Susanne A, Klein Christine, Deuschl Günther, van Eimeren Thilo, Witt Karsten
Abstract excerpt
Previous receptor binding studies suggest dopamine function is altered in the basal ganglia circuitry in task-specific dystonia, a condition characterized by contraction of agonist and antagonist muscles while performing specific tasks. Dopamine plays a role in reward-based learning. Using fMRI, this study compared 31 right-handed writer's cramp patients to 35 controls in reward-based learning of a probabilistic...
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