Article

D2 dopamine receptor expression, sensitivity to rewards, and reinforcement learning in a complex value-based decision-making task

2022-02-19

Abstract excerpt

In the basal ganglia, different dopamine subtypes have opposing dynamics at post-synaptic receptors, with the ratio of D1 to D2 receptors determining the relative sensitivity to gains and losses, respectively, during value-based learning. This effective sensitivity to reward feedback interacts with phasic dopamine levels to determine the effectiveness of learning, particularly in dynamic feedback situations where...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d682533-d789-5c5d-a72c-d932a1cf3264
DOI: 10.1101/2022.02.18.481052

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

D2 dopamine receptor expression, sensitivity to rewards, and reinforcement learning in a complex value-based decision-making taskDOI 10.1101/2022.02.18.481052Read

Genetically determined differences in learning from errors.Semantic proximity Read

Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function.Semantic proximity Read

Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions.Semantic proximity Read

Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine functionSemantic proximity Read

Dissociable contribution of prefrontal and striatal dopaminergic genes to learning in economic games.Semantic proximity Read

Commonly-occurring polymorphisms in the COMT, DRD1 and DRD2 genes influence different aspects of motor sequence learning in humans.Semantic proximity Read

How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis.Semantic proximity Read

Role of dopamine D2 receptors in human reinforcement learning.Semantic proximity Read

Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms.Semantic proximity Read

Variability in Dopamine Genes Dissociates Model-Based and Model-Free Reinforcement Learning.Semantic proximity Read

The C957T polymorphism in the dopamine receptor D₂ gene modulates domain-general category learning.Semantic proximity Read

Contextual influence of reinforcement learning performance in depression: evidence for a negativity bias?Semantic proximity Read