Article
Genetically determined differences in learning from errors.
Science (New York, N.Y.) - 7 Dec 2007
Klein Tilmann A, Neumann Jane, Reuter Martin, Hennig Jürgen, von Cramon D Yves, Ullsperger Markus
Abstract excerpt
The role of dopamine in monitoring negative action outcomes and feedback-based learning was tested in a neuroimaging study in humans grouped according to the dopamine D2 receptor gene polymorphism DRD2-TAQ-IA. In a probabilistic learning task, A1-allele carriers with reduced dopamine D2 receptor densities learned to avoid actions with negative consequences less efficiently. Their posterior medial frontal cortex...
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