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Article

Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions.

Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2009

Krugel Lea K, Biele Guido, Mohr Peter N C, Li Shu-Chen, Heekeren Hauke R

Abstract excerpt

The ability to rapidly and flexibly adapt decisions to available rewards is crucial for survival in dynamic environments. Reward-based decisions are guided by reward expectations that are updated based on prediction errors, and processing of these errors involves dopaminergic neuromodulation in the striatum. To test the hypothesis that the COMT gene Val(158)Met polymorphism leads to interindividual differences in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19822738
DOI: 10.1073/pnas.0905191106
PMCID: PMC2760487

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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