Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype.

Brain : a journal of neurology - 5 Dec 2020

van Nuland Annelies J, Helmich Rick C, Dirkx Michiel F, Zach Heidemarie, Toni Ivan, Cools Roshan, den Ouden Hanneke E M

Abstract excerpt

Parkinson's disease is clinically defined by bradykinesia, along with rigidity and tremor. However, the severity of these motor signs is greatly variable between individuals, particularly the presence or absence of tremor. This variability in tremor relates to variation in cognitive/motivational impairment, as well as the spatial distribution of neurodegeneration in the midbrain and dopamine depletion in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiparkinson Agents
Share to Conditioning, Operant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine Agonists

Share to Learning

Share to Levodopa

Share to Motivation

Share to Reward

Share to Tremor

Source

Open in PubMed Open full text

Identifiers

PMID: 33147621
DOI: 10.1093/brain/awaa335
PMCID: PMC7719026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype.PMID 33147621Read ↗

Tremor in Parkinson's disease inverts the effect of dopamine on reinforcement.Semantic proximity Read ↗

Genetic variation in the dopamine system is associated with mixed-strategy decision-making in patients with Parkinson's disease.Semantic proximity Read ↗

Dopamine depletion in Parkinson’s increases directed but not random explorationSemantic proximity Read ↗

Dopaminergic reinforcement in the motor system: Implications for Parkinson’s disease and deep brain stimulationSemantic proximity Read ↗

Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function.Semantic proximity Read ↗

Motor sequence learning deficits in idiopathic Parkinson’s disease are associated with increased substantia nigra activitySemantic proximity Read ↗

Encoding Motivation Prediction Errors in the Human Dopaminergic Reward SystemSemantic proximity Read ↗

Task-dependent interactions between dopamine D2 receptor polymorphisms and L-DOPA in patients with Parkinson's disease.Semantic proximity Read ↗

Modulation of motor vigour by expectation of reward probability trial-by-trial is preserved in healthy ageing and Parkinson’s disease patientsSemantic proximity Read ↗

The role of dopamine in cognitive sequence learning: evidence from Parkinson’s diseaseSemantic proximity Read ↗

Altered brain activation in a reversal learning task unmasks adaptive changes in cognitive control in writer's cramp.Semantic proximity Read ↗

Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.