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Article

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis

2 Dec 2015

Abstract excerpt

INTRODUCTION: In liver fibrosis activation of hepatic stellate cells (HSC) comprises phenotypical change into profibrotic and myofibroplastic cells with increased contraction and secretion of extracellular matrix (ECM) proteins. The small GTPase RhoA orchestrates cytoskeleton formation, migration, and mobility via non-receptor tyrosine-protein kinase c-SRC (cellular sarcoma) in different cells. Furthermore, RhoA...

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Share to Hepatocellular Carcinoma Treatment and Prognosis
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PMID: 26696895
DOI: 10.3389/fphys.2015.00359

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