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Article

Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells.

PloS one - 1 Jan 2015

Giehl Klaudia, Keller Christof, Muehlich Susanne, Goppelt-Struebe Margarete

Abstract excerpt

Morphological alterations of cells can lead to modulation of gene expression. An essential link is the MKL1-dependent activation of serum response factor (SRF), which translates changes in the ratio of G- and F-actin into mRNA transcription. SRF activation is only partially characterized in non-t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25816094
DOI: 10.1371/journal.pone.0121589
PMCID: PMC4376694

Genes

SRF
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25816094-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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