Article
CXCL12 induces hepatic stellate cell contraction through a calcium-independent pathway.
American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2013
Saiman Yedidya, Agarwal Ritu, Hickman DaShawn A, Fausther Michel, El-Shamy Ahmed, Dranoff Jonathan A, Friedman Scott L, Bansal Meena B
Abstract excerpt
Liver fibrosis, with subsequent development of cirrhosis and ultimately portal hypertension, results in the death of patients with end-stage liver disease if liver transplantation is not performed. Hepatic stellate cells (HSCs), central mediators of liver fibrosis, resemble tissue pericytes and regulate intrahepatic blood flow by modulating pericapillary resistance. Therefore, HSCs can contribute to portal...
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