Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Desensitization of the PDGFbeta receptor by modulation of the cytoskeleton: the role of p21(Ras) and Rho family GTPases.

Experimental cell research - 15 Apr 2002

Stice Ligaya L, Forman Lora W, Hahn Chang S, Faller Douglas V

Abstract excerpt

Ligand-induced PDGF-type beta receptor (PDGFbeta-R) autophosphorylation is profoundly suppressed in cells transformed by activated p21(Ras). We report here that the integrity of the actin cytoskeleton is a critical regulator of PDGFbeta-R function in the presence of p21(Ras). Morphological reversion of Balb cells expressing a constitutively activated p21(Ras), with re-formation of actin stress fibers and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to rho GTP-Binding Proteins
Share to Vanadates

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to 3T3 Cells

Share to Actins

Share to Cell Line, Transformed

Share to Cytoskeleton

Share to Enzyme Inhibitors

Share to Receptor, Platelet-Derived Growth Factor beta

Source

Identifiers

PMID: 11925102
DOI: 10.1006/excr.2002.5482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Desensitization of the PDGFbeta receptor by modulation of the cytoskeleton: the role of p21(Ras) and Rho family GTPases.PMID 11925102Read ↗

Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alphaSemantic proximity Read ↗

Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation.Semantic proximity Read ↗

Integrin-mediated signals regulated by members of the rho family of GTPases.Semantic proximity Read ↗

R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.Semantic proximity Read ↗

Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.Semantic proximity Read ↗

A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival.Semantic proximity Read ↗

Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts.Semantic proximity Read ↗

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior.Semantic proximity Read ↗

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.Semantic proximity Read ↗

Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB.Semantic proximity Read ↗

Analysis of R-Ras signalling pathways.Semantic proximity Read ↗

The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.